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    Scottish Labour MP to vote against welfare reforms despite Keir Starmer climbdown

    Scottish Labour MP to vote against welfare reforms despite Keir Starmer climbdown

    Buy British buses to save 400 Scottish jobs at Alexander Dennis, says MP

    Buy British buses to save 400 Scottish jobs at Alexander Dennis, says MP

    Scots fear crime is rising in their local area as SNP Government accused of ‘hollowing out’ police

    Scots fear crime is rising in their local area as SNP Government accused of ‘hollowing out’ police

    Senior member of Anas Sarwar’s shadow cabinet ‘opposed’ to Labour welfare cuts bill

    Senior member of Anas Sarwar’s shadow cabinet ‘opposed’ to Labour welfare cuts bill

    How the Scottish MPs voted in the assisted dying debate

    How the Scottish MPs voted in the assisted dying debate

    Former Labour MP calls for party to ditch ‘rigged’ voting system

    Former Labour MP calls for party to ditch ‘rigged’ voting system

    Labour’s £14bn ‘fixation’ with new nuclear power ‘won’t cut bills or help climate’

    Labour’s £14bn ‘fixation’ with new nuclear power ‘won’t cut bills or help climate’

    SNP rebels plot to oust John Swinney as party leader after Hamilton by-election loss

    SNP rebels plot to oust John Swinney as party leader after Hamilton by-election loss

    Anas Sarwar should not expect to oust John Swinney yet, says polling guru

    Anas Sarwar should not expect to oust John Swinney yet, says polling guru

    Keir Starmer says he will not support a second independence referendum as Prime Minister

    Keir Starmer says he will not support a second independence referendum as Prime Minister

    Angela Rayner accuses Reform of ‘politics of hatred’ as she insists Labour can win bitter Holyrood by-election

    Angela Rayner accuses Reform of ‘politics of hatred’ as she insists Labour can win bitter Holyrood by-election

    SNP complain about Reform’s ‘race-baiting’ advert on Scottish Labour leader Anas Sarwar

    SNP complain about Reform’s ‘race-baiting’ advert on Scottish Labour leader Anas Sarwar

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    • Business

      Salesforce boss Marc Benioff joins Weev.

      What is a virtual office and why you need one in Central London – Your Company Formations Ltd

      What is a virtual office and why you need one in Central London – Your Company Formations Ltd

      Inflation rises again to new 40-year high

      Inflation rises again to new 40-year high

      Bank of England hikes interest rates to 1.25%

      Bank of England hikes interest rates to 1.25%

      Hiring activity in Scotland slows amid steep decline in staff availability

      Hiring activity in Scotland slows amid steep decline in staff availability

      Scottish retail footfall growth ‘worst in UK compared to pre-pandemic’

      Scottish retail footfall growth ‘worst in UK compared to pre-pandemic’

    • Sports
      Exact cost of Rangers injury crisis revealed as payments to crocked stars double that of Celtic

      Exact cost of Rangers injury crisis revealed as payments to crocked stars double that of Celtic

      Conor Coady in Diogo Jota tribute as old Wolves pal celebrates an ‘incredible person’

      Conor Coady in Diogo Jota tribute as old Wolves pal celebrates an ‘incredible person’

      Brendan Rodgers described me as huge Celtic coup after 24 clubs wanted me – now I have retired aged just 28

      Brendan Rodgers described me as huge Celtic coup after 24 clubs wanted me – now I have retired aged just 28

      Ange Postecoglou to LAFC has direct Celtic link as MLS heavy hitters plot ambitious manager move

      Ange Postecoglou to LAFC has direct Celtic link as MLS heavy hitters plot ambitious manager move

      The Rangers transfers Russell Martin needs revealed as AEK set Dessers deadline and Shankland a no-brainer

      The Rangers transfers Russell Martin needs revealed as AEK set Dessers deadline and Shankland a no-brainer

      Celtic on brink of four new signings as Benjamin Nygren lands staggering transfer claim and Balikwisha stays cool

      Celtic on brink of four new signings as Benjamin Nygren lands staggering transfer claim and Balikwisha stays cool

      I see cracks in Celtic with transfer fears over four starters so maybe this Rangers claim is a myth – Hugh Keevins

      I see cracks in Celtic with transfer fears over four starters so maybe this Rangers claim is a myth – Hugh Keevins

      Punters dramatically lose faith in Rory McIlroy in wake of his astonishingly honest US Open confession

      Punters dramatically lose faith in Rory McIlroy in wake of his astonishingly honest US Open confession

      ‘I still always visit Sir Alex Ferguson’s house – even though he branded me a Big Time Charlie’

      ‘I still always visit Sir Alex Ferguson’s house – even though he branded me a Big Time Charlie’

      The £17m reason Celtic won’t sit still this transfer window as Brendan Rodgers learns painful lesson

      The £17m reason Celtic won’t sit still this transfer window as Brendan Rodgers learns painful lesson

      Rangers placed on Vaclav Cerny red alert over Wolfsburg ‘fire sale’ as Cyriel Dessers makes transfer stance clear

      Rangers placed on Vaclav Cerny red alert over Wolfsburg ‘fire sale’ as Cyriel Dessers makes transfer stance clear

      Mathias Kvistgaarden waves Brondby farewell but Celtic hit with transfer blow as boss throws spanner in works

      Mathias Kvistgaarden waves Brondby farewell but Celtic hit with transfer blow as boss throws spanner in works

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      • Technology
        ‘Classy’ smartwatch that ‘performs as well as expensive brands’ now £50 in Amazon Prime deal

        ‘Classy’ smartwatch that ‘performs as well as expensive brands’ now £50 in Amazon Prime deal

        Argos offers free QLED TVs with one simple deal – how to get yours today

        Argos offers free QLED TVs with one simple deal – how to get yours today

        Everyone to get mobile phone alert as sirens sound for 10 seconds

        Everyone to get mobile phone alert as sirens sound for 10 seconds

        Lenovo IdeaPad laptop praised for everyday use and affordable price

        Lenovo IdeaPad laptop praised for everyday use and affordable price

        EE unveils huge new discount on JBL Flip 7 Wireless Bluetooth Speaker but you must act quick

        EE unveils huge new discount on JBL Flip 7 Wireless Bluetooth Speaker but you must act quick

      • Health
        Clinical microbiologist issues warning over hidden ‘droppings’ in bed sheets

        Clinical microbiologist issues warning over hidden ‘droppings’ in bed sheets

        Scientists just found a sugar switch that ‘protects your brain from Alzheimer’s’

        Scientists just found a sugar switch that ‘protects your brain from Alzheimer’s’

        Brain dead pregnant woman’s family issue update after baby cut from her body

        Brain dead pregnant woman’s family issue update after baby cut from her body

        French chef shares ‘simplest ever’ one pot cake recipe ready in under an hour

        French chef shares ‘simplest ever’ one pot cake recipe ready in under an hour

        TikTok skin care routines ‘harmful’ and ‘problematic’ scientists discover in new study

        TikTok skin care routines ‘harmful’ and ‘problematic’ scientists discover in new study

      • Entertainment
        People on highest PIP could see payments rise to nearly £800 each month from next April

        People on highest PIP could see payments rise to nearly £800 each month from next April

        Home Bargains’ ‘soft’ £30 coat looks ‘just like’ £175 Dryrobe version

        Home Bargains’ ‘soft’ £30 coat looks ‘just like’ £175 Dryrobe version

        Amazon’s most wished for sun lounger drops below £90 ahead of Prime Day

        Amazon’s most wished for sun lounger drops below £90 ahead of Prime Day

        Former DWP employee warns of two-tier State Pension payments for older people

        Former DWP employee warns of two-tier State Pension payments for older people

        Dozens of UK holidaymakers fall ill after five-star ‘holiday from hell’

        Dozens of UK holidaymakers fall ill after five-star ‘holiday from hell’

      • Life Style
      • Travel
      • Education
        Lecturer struck off after falling asleep, playing on his phone and describing students as ‘d*** heads’

        Lecturer struck off after falling asleep, playing on his phone and describing students as ‘d*** heads’

        Teacher who drank alcohol in ‘mini-rave’ lesson and swore at pupils is struck off

        Teacher who drank alcohol in ‘mini-rave’ lesson and swore at pupils is struck off

        Pupil referral unit that takes children kicked out of school gets flawless Estyn report

        Pupil referral unit that takes children kicked out of school gets flawless Estyn report

        Exam bosses accused of ‘patronising’ Wales and students in Welsh GCSE paper

        Exam bosses accused of ‘patronising’ Wales and students in Welsh GCSE paper

        Cardiff University ‘has no God given right to exist’ bosses say

        Cardiff University ‘has no God given right to exist’ bosses say

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      • Home
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      • Politics
        Scottish Labour MP to vote against welfare reforms despite Keir Starmer climbdown

        Scottish Labour MP to vote against welfare reforms despite Keir Starmer climbdown

        Buy British buses to save 400 Scottish jobs at Alexander Dennis, says MP

        Buy British buses to save 400 Scottish jobs at Alexander Dennis, says MP

        Scots fear crime is rising in their local area as SNP Government accused of ‘hollowing out’ police

        Scots fear crime is rising in their local area as SNP Government accused of ‘hollowing out’ police

        Senior member of Anas Sarwar’s shadow cabinet ‘opposed’ to Labour welfare cuts bill

        Senior member of Anas Sarwar’s shadow cabinet ‘opposed’ to Labour welfare cuts bill

        How the Scottish MPs voted in the assisted dying debate

        How the Scottish MPs voted in the assisted dying debate

        Former Labour MP calls for party to ditch ‘rigged’ voting system

        Former Labour MP calls for party to ditch ‘rigged’ voting system

        Labour’s £14bn ‘fixation’ with new nuclear power ‘won’t cut bills or help climate’

        Labour’s £14bn ‘fixation’ with new nuclear power ‘won’t cut bills or help climate’

        SNP rebels plot to oust John Swinney as party leader after Hamilton by-election loss

        SNP rebels plot to oust John Swinney as party leader after Hamilton by-election loss

        Anas Sarwar should not expect to oust John Swinney yet, says polling guru

        Anas Sarwar should not expect to oust John Swinney yet, says polling guru

        Keir Starmer says he will not support a second independence referendum as Prime Minister

        Keir Starmer says he will not support a second independence referendum as Prime Minister

        Angela Rayner accuses Reform of ‘politics of hatred’ as she insists Labour can win bitter Holyrood by-election

        Angela Rayner accuses Reform of ‘politics of hatred’ as she insists Labour can win bitter Holyrood by-election

        SNP complain about Reform’s ‘race-baiting’ advert on Scottish Labour leader Anas Sarwar

        SNP complain about Reform’s ‘race-baiting’ advert on Scottish Labour leader Anas Sarwar

        Trending Tags

        • Business

          Salesforce boss Marc Benioff joins Weev.

          What is a virtual office and why you need one in Central London – Your Company Formations Ltd

          What is a virtual office and why you need one in Central London – Your Company Formations Ltd

          Inflation rises again to new 40-year high

          Inflation rises again to new 40-year high

          Bank of England hikes interest rates to 1.25%

          Bank of England hikes interest rates to 1.25%

          Hiring activity in Scotland slows amid steep decline in staff availability

          Hiring activity in Scotland slows amid steep decline in staff availability

          Scottish retail footfall growth ‘worst in UK compared to pre-pandemic’

          Scottish retail footfall growth ‘worst in UK compared to pre-pandemic’

        • Sports
          Exact cost of Rangers injury crisis revealed as payments to crocked stars double that of Celtic

          Exact cost of Rangers injury crisis revealed as payments to crocked stars double that of Celtic

          Conor Coady in Diogo Jota tribute as old Wolves pal celebrates an ‘incredible person’

          Conor Coady in Diogo Jota tribute as old Wolves pal celebrates an ‘incredible person’

          Brendan Rodgers described me as huge Celtic coup after 24 clubs wanted me – now I have retired aged just 28

          Brendan Rodgers described me as huge Celtic coup after 24 clubs wanted me – now I have retired aged just 28

          Ange Postecoglou to LAFC has direct Celtic link as MLS heavy hitters plot ambitious manager move

          Ange Postecoglou to LAFC has direct Celtic link as MLS heavy hitters plot ambitious manager move

          The Rangers transfers Russell Martin needs revealed as AEK set Dessers deadline and Shankland a no-brainer

          The Rangers transfers Russell Martin needs revealed as AEK set Dessers deadline and Shankland a no-brainer

          Celtic on brink of four new signings as Benjamin Nygren lands staggering transfer claim and Balikwisha stays cool

          Celtic on brink of four new signings as Benjamin Nygren lands staggering transfer claim and Balikwisha stays cool

          I see cracks in Celtic with transfer fears over four starters so maybe this Rangers claim is a myth – Hugh Keevins

          I see cracks in Celtic with transfer fears over four starters so maybe this Rangers claim is a myth – Hugh Keevins

          Punters dramatically lose faith in Rory McIlroy in wake of his astonishingly honest US Open confession

          Punters dramatically lose faith in Rory McIlroy in wake of his astonishingly honest US Open confession

          ‘I still always visit Sir Alex Ferguson’s house – even though he branded me a Big Time Charlie’

          ‘I still always visit Sir Alex Ferguson’s house – even though he branded me a Big Time Charlie’

          The £17m reason Celtic won’t sit still this transfer window as Brendan Rodgers learns painful lesson

          The £17m reason Celtic won’t sit still this transfer window as Brendan Rodgers learns painful lesson

          Rangers placed on Vaclav Cerny red alert over Wolfsburg ‘fire sale’ as Cyriel Dessers makes transfer stance clear

          Rangers placed on Vaclav Cerny red alert over Wolfsburg ‘fire sale’ as Cyriel Dessers makes transfer stance clear

          Mathias Kvistgaarden waves Brondby farewell but Celtic hit with transfer blow as boss throws spanner in works

          Mathias Kvistgaarden waves Brondby farewell but Celtic hit with transfer blow as boss throws spanner in works

          Trending Tags

          • Technology
            ‘Classy’ smartwatch that ‘performs as well as expensive brands’ now £50 in Amazon Prime deal

            ‘Classy’ smartwatch that ‘performs as well as expensive brands’ now £50 in Amazon Prime deal

            Argos offers free QLED TVs with one simple deal – how to get yours today

            Argos offers free QLED TVs with one simple deal – how to get yours today

            Everyone to get mobile phone alert as sirens sound for 10 seconds

            Everyone to get mobile phone alert as sirens sound for 10 seconds

            Lenovo IdeaPad laptop praised for everyday use and affordable price

            Lenovo IdeaPad laptop praised for everyday use and affordable price

            EE unveils huge new discount on JBL Flip 7 Wireless Bluetooth Speaker but you must act quick

            EE unveils huge new discount on JBL Flip 7 Wireless Bluetooth Speaker but you must act quick

          • Health
            Clinical microbiologist issues warning over hidden ‘droppings’ in bed sheets

            Clinical microbiologist issues warning over hidden ‘droppings’ in bed sheets

            Scientists just found a sugar switch that ‘protects your brain from Alzheimer’s’

            Scientists just found a sugar switch that ‘protects your brain from Alzheimer’s’

            Brain dead pregnant woman’s family issue update after baby cut from her body

            Brain dead pregnant woman’s family issue update after baby cut from her body

            French chef shares ‘simplest ever’ one pot cake recipe ready in under an hour

            French chef shares ‘simplest ever’ one pot cake recipe ready in under an hour

            TikTok skin care routines ‘harmful’ and ‘problematic’ scientists discover in new study

            TikTok skin care routines ‘harmful’ and ‘problematic’ scientists discover in new study

          • Entertainment
            People on highest PIP could see payments rise to nearly £800 each month from next April

            People on highest PIP could see payments rise to nearly £800 each month from next April

            Home Bargains’ ‘soft’ £30 coat looks ‘just like’ £175 Dryrobe version

            Home Bargains’ ‘soft’ £30 coat looks ‘just like’ £175 Dryrobe version

            Amazon’s most wished for sun lounger drops below £90 ahead of Prime Day

            Amazon’s most wished for sun lounger drops below £90 ahead of Prime Day

            Former DWP employee warns of two-tier State Pension payments for older people

            Former DWP employee warns of two-tier State Pension payments for older people

            Dozens of UK holidaymakers fall ill after five-star ‘holiday from hell’

            Dozens of UK holidaymakers fall ill after five-star ‘holiday from hell’

          • Life Style
          • Travel
          • Education
            Lecturer struck off after falling asleep, playing on his phone and describing students as ‘d*** heads’

            Lecturer struck off after falling asleep, playing on his phone and describing students as ‘d*** heads’

            Teacher who drank alcohol in ‘mini-rave’ lesson and swore at pupils is struck off

            Teacher who drank alcohol in ‘mini-rave’ lesson and swore at pupils is struck off

            Pupil referral unit that takes children kicked out of school gets flawless Estyn report

            Pupil referral unit that takes children kicked out of school gets flawless Estyn report

            Exam bosses accused of ‘patronising’ Wales and students in Welsh GCSE paper

            Exam bosses accused of ‘patronising’ Wales and students in Welsh GCSE paper

            Cardiff University ‘has no God given right to exist’ bosses say

            Cardiff University ‘has no God given right to exist’ bosses say

          • Real Estate
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          Breakthrough cancer study finds big ‘clues’ about how disease is caused

          by Annie A. McGinnis
          April 22, 2022
          in Health
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          A major step toward the personalisation of cancer treatment was made by an analysis of thousands of tumours that uncovered a treasure trove of clues about how the disease is caused.

          It is the first time it has been possible to detect patterns in cancer DNA, said researchers.

          The patterns – called mutational signatures – provide clues, including about whether a patient has had exposure to environmental causes of cancer such as smoking or UV light, for example.

          This is important as these signatures allow doctors to look at each patient’s tumour and match it to specific treatments and medications.

          However, these patterns can only be detected through the analysis of the vast amounts of data unearthed by whole genome sequencing – identifying the genetic make-up of a cell.



          Attractive young woman tanning in solarium and smiling.
          Cancer DNA could indicate exposure to environmental causes of cancer such as smoking or UV light
          (Image: Getty Images/iStockphoto)
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          Principal author Serena Nik-Zainal is a professor of genomic medicine and bioinformatics at the University of Cambridge and an honorary consultant in clinical genetics at Cambridge University Hospitals.

          She said: “It’s like looking at a very busy beach with thousands of footprints in the sand.

          “To the untrained eye, the footprints appear to be random and meaningless.

          “But if you are able to study them closely, you can learn a lot about what’s been going on, distinguish between animal and human prints, whether it’s an adult or child, what direction they’re travelling in, etc.

          “It’s the same thing with the mutational signatures.

          “The use of whole genome sequencing can identify which ‘footprints’ are relevant/important and reveal what’s happened through the development of the cancer.”

          Researchers analysed the complete genetic make-up or whole genome sequences (WGS) of more than 12,000 NHS cancer patients.

          They were able to spot 58 new mutational signatures, suggesting that there are additional causes of cancer that are not yet fully understood.

          Prof Nik-Zainal said: “The reason it is important to identify mutational signatures is because they are like fingerprints at a crime scene – they help to pinpoint cancer culprits.

          “Some mutational signatures have clinical or treatment implications – they can highlight abnormalities that may be targeted with specific drugs or may indicate a potential ‘Achilles heel’ in individual cancers.”

          Dr Andrea Degasperi, research associate at the University of Cambridge and first author, said: “Whole genome sequencing gives us a total picture of all the mutations that have contributed to each person’s cancer.

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          “With thousands of mutations per cancer, we have unprecedented power to look for commonalities and differences across NHS patients, and in doing so we uncovered 58 new mutational signatures and broadened our knowledge of cancer.”

          The findings are now being incorporated into the NHS as researchers and clinicians now have the use of a digital tool called FitMS that will help them identify the mutational signature and potentially inform cancer management more effectively.

          This research was supported by Cancer Research UK and published in the journal Science.

          The genomic data was provided by the 100,000 Genomes Project, an England-wide clinical research programme to sequence 100,000 whole genomes from around 85,000 patients affected by rare disease or cancer.

          Michelle Mitchell, chief executive of Cancer Research UK, said: “This study shows how powerful whole genome sequencing tests can be in giving clues into how the cancer may have developed, how it will behave and what treatment options would work best.”

          Professor Matt Brown, chief scientific officer of Genomics England, said: “Mutational signatures are an example of using the full potential of WGS.

          “We hope to use the mutational clues seen in this study and apply them back into our patient population, with the ultimate aim of improving diagnosis and management of cancer patients.”





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