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    Nicola Sturgeon agrees to TV special as ex-SNP leader to be grilled on ‘striking revelations’ in new book

    Nicola Sturgeon agrees to TV special as ex-SNP leader to be grilled on ‘striking revelations’ in new book

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    Donald Trump diary reveals exact time he will arrive in Scotland

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    Scots ‘forced to wait years’ for hernia operations as NHS struggles to meet demand

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    System must work to protect public as report finds chances missed with Southport killer

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    NHS in Scotland ‘stuck in analogue age’ as health boards shell out millions on pagers

    Scottish Labour MP to vote against welfare reforms despite Keir Starmer climbdown

    Scottish Labour MP to vote against welfare reforms despite Keir Starmer climbdown

    Buy British buses to save 400 Scottish jobs at Alexander Dennis, says MP

    Buy British buses to save 400 Scottish jobs at Alexander Dennis, says MP

    Scots fear crime is rising in their local area as SNP Government accused of ‘hollowing out’ police

    Scots fear crime is rising in their local area as SNP Government accused of ‘hollowing out’ police

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    Senior member of Anas Sarwar’s shadow cabinet ‘opposed’ to Labour welfare cuts bill

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    How the Scottish MPs voted in the assisted dying debate

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    Former Labour MP calls for party to ditch ‘rigged’ voting system

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      Inflation rises again to new 40-year high

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      Bank of England hikes interest rates to 1.25%

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      Hiring activity in Scotland slows amid steep decline in staff availability

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      Prince William’s firm five-word statement to Chloe Kelly about Euros goal uncovered by lip reader

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      Kieran Tierney genius exposes ‘sloppy’ Ajax as Celtic earn rival acclaim despite Como Cup hammering

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      Andrej Bacanin makes Celtic transfer intentions clear amid Rangers claim as direct link with Lennon Miller emerges

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      Rangers strongest XI for Panathinaikos as Thelo Aasgaard injury blow opens door for Euro history-maker

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      Celtic could ‘renew interest’ in Evan Ferguson as transfer hijack follows Yamada hint and Ambrosino U turn

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      Exact cost of Rangers injury crisis revealed as payments to crocked stars double that of Celtic

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      Conor Coady in Diogo Jota tribute as old Wolves pal celebrates an ‘incredible person’

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      Brendan Rodgers described me as huge Celtic coup after 24 clubs wanted me – now I have retired aged just 28

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      Ange Postecoglou to LAFC has direct Celtic link as MLS heavy hitters plot ambitious manager move

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      The Rangers transfers Russell Martin needs revealed as AEK set Dessers deadline and Shankland a no-brainer

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      Celtic on brink of four new signings as Benjamin Nygren lands staggering transfer claim and Balikwisha stays cool

      I see cracks in Celtic with transfer fears over four starters so maybe this Rangers claim is a myth – Hugh Keevins

      I see cracks in Celtic with transfer fears over four starters so maybe this Rangers claim is a myth – Hugh Keevins

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        Argos offers free QLED TVs with one simple deal – how to get yours today

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        Tesco shoppers ‘run’ to stores for ‘gorgeous’ £29.50 cardigan

        Former DWP employee urges all parents to claim Child Benefit to boost State Pension payments

        Former DWP employee urges all parents to claim Child Benefit to boost State Pension payments

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        DWP boss defends welfare reform changes after PIP plans put on hold

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        People on highest PIP could see payments rise to nearly £800 each month from next April

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        Home Bargains’ ‘soft’ £30 coat looks ‘just like’ £175 Dryrobe version

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        Fury as Welsh Government rejects recommended 4.8% pay rise for teachers

        Fury as Welsh Government rejects recommended 4.8% pay rise for teachers

        Vocational skills to be offered at new secondary school in Swansea

        Vocational skills to be offered at new secondary school in Swansea

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        Lecturer struck off after falling asleep, playing on his phone and describing students as ‘d*** heads’

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        Teacher who drank alcohol in ‘mini-rave’ lesson and swore at pupils is struck off

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        Pupil referral unit that takes children kicked out of school gets flawless Estyn report

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        Nicola Sturgeon agrees to TV special as ex-SNP leader to be grilled on ‘striking revelations’ in new book

        Nicola Sturgeon agrees to TV special as ex-SNP leader to be grilled on ‘striking revelations’ in new book

        Donald Trump diary reveals exact time he will arrive in Scotland

        Donald Trump diary reveals exact time he will arrive in Scotland

        Scots ‘forced to wait years’ for hernia operations as NHS struggles to meet demand

        Scots ‘forced to wait years’ for hernia operations as NHS struggles to meet demand

        System must work to protect public as report finds chances missed with Southport killer

        System must work to protect public as report finds chances missed with Southport killer

        NHS in Scotland ‘stuck in analogue age’ as health boards shell out millions on pagers

        NHS in Scotland ‘stuck in analogue age’ as health boards shell out millions on pagers

        Scottish Labour MP to vote against welfare reforms despite Keir Starmer climbdown

        Scottish Labour MP to vote against welfare reforms despite Keir Starmer climbdown

        Buy British buses to save 400 Scottish jobs at Alexander Dennis, says MP

        Buy British buses to save 400 Scottish jobs at Alexander Dennis, says MP

        Scots fear crime is rising in their local area as SNP Government accused of ‘hollowing out’ police

        Scots fear crime is rising in their local area as SNP Government accused of ‘hollowing out’ police

        Senior member of Anas Sarwar’s shadow cabinet ‘opposed’ to Labour welfare cuts bill

        Senior member of Anas Sarwar’s shadow cabinet ‘opposed’ to Labour welfare cuts bill

        How the Scottish MPs voted in the assisted dying debate

        How the Scottish MPs voted in the assisted dying debate

        Former Labour MP calls for party to ditch ‘rigged’ voting system

        Former Labour MP calls for party to ditch ‘rigged’ voting system

        Labour’s £14bn ‘fixation’ with new nuclear power ‘won’t cut bills or help climate’

        Labour’s £14bn ‘fixation’ with new nuclear power ‘won’t cut bills or help climate’

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          Salesforce boss Marc Benioff joins Weev.

          What is a virtual office and why you need one in Central London – Your Company Formations Ltd

          What is a virtual office and why you need one in Central London – Your Company Formations Ltd

          Inflation rises again to new 40-year high

          Inflation rises again to new 40-year high

          Bank of England hikes interest rates to 1.25%

          Bank of England hikes interest rates to 1.25%

          Hiring activity in Scotland slows amid steep decline in staff availability

          Hiring activity in Scotland slows amid steep decline in staff availability

          Scottish retail footfall growth ‘worst in UK compared to pre-pandemic’

          Scottish retail footfall growth ‘worst in UK compared to pre-pandemic’

        • Sports
          Prince William’s firm five-word statement to Chloe Kelly about Euros goal uncovered by lip reader

          Prince William’s firm five-word statement to Chloe Kelly about Euros goal uncovered by lip reader

          Kieran Tierney genius exposes ‘sloppy’ Ajax as Celtic earn rival acclaim despite Como Cup hammering

          Kieran Tierney genius exposes ‘sloppy’ Ajax as Celtic earn rival acclaim despite Como Cup hammering

          Andrej Bacanin makes Celtic transfer intentions clear amid Rangers claim as direct link with Lennon Miller emerges

          Andrej Bacanin makes Celtic transfer intentions clear amid Rangers claim as direct link with Lennon Miller emerges

          Rangers strongest XI for Panathinaikos as Thelo Aasgaard injury blow opens door for Euro history-maker

          Rangers strongest XI for Panathinaikos as Thelo Aasgaard injury blow opens door for Euro history-maker

          Celtic could ‘renew interest’ in Evan Ferguson as transfer hijack follows Yamada hint and Ambrosino U turn

          Celtic could ‘renew interest’ in Evan Ferguson as transfer hijack follows Yamada hint and Ambrosino U turn

          Exact cost of Rangers injury crisis revealed as payments to crocked stars double that of Celtic

          Exact cost of Rangers injury crisis revealed as payments to crocked stars double that of Celtic

          Conor Coady in Diogo Jota tribute as old Wolves pal celebrates an ‘incredible person’

          Conor Coady in Diogo Jota tribute as old Wolves pal celebrates an ‘incredible person’

          Brendan Rodgers described me as huge Celtic coup after 24 clubs wanted me – now I have retired aged just 28

          Brendan Rodgers described me as huge Celtic coup after 24 clubs wanted me – now I have retired aged just 28

          Ange Postecoglou to LAFC has direct Celtic link as MLS heavy hitters plot ambitious manager move

          Ange Postecoglou to LAFC has direct Celtic link as MLS heavy hitters plot ambitious manager move

          The Rangers transfers Russell Martin needs revealed as AEK set Dessers deadline and Shankland a no-brainer

          The Rangers transfers Russell Martin needs revealed as AEK set Dessers deadline and Shankland a no-brainer

          Celtic on brink of four new signings as Benjamin Nygren lands staggering transfer claim and Balikwisha stays cool

          Celtic on brink of four new signings as Benjamin Nygren lands staggering transfer claim and Balikwisha stays cool

          I see cracks in Celtic with transfer fears over four starters so maybe this Rangers claim is a myth – Hugh Keevins

          I see cracks in Celtic with transfer fears over four starters so maybe this Rangers claim is a myth – Hugh Keevins

          Trending Tags

          • Technology
            Lego Game Boy unveiled with pre-orders now live – but some point out ‘disappointing’ flaw

            Lego Game Boy unveiled with pre-orders now live – but some point out ‘disappointing’ flaw

            Panasonic dishes out £100 takeaway vouchers and 15% off ‘first class’ OLED TVs

            Panasonic dishes out £100 takeaway vouchers and 15% off ‘first class’ OLED TVs

            ‘Classy’ smartwatch that ‘performs as well as expensive brands’ now £50 in Amazon Prime deal

            ‘Classy’ smartwatch that ‘performs as well as expensive brands’ now £50 in Amazon Prime deal

            Argos offers free QLED TVs with one simple deal – how to get yours today

            Argos offers free QLED TVs with one simple deal – how to get yours today

            Everyone to get mobile phone alert as sirens sound for 10 seconds

            Everyone to get mobile phone alert as sirens sound for 10 seconds

          • Health
            ‘I used old-fashioned method to lose 4stone after microwave incident’

            ‘I used old-fashioned method to lose 4stone after microwave incident’

            Donald Trump medical condition diagnosed as US President suffers swollen legs

            Donald Trump medical condition diagnosed as US President suffers swollen legs

            Clinical microbiologist issues warning over hidden ‘droppings’ in bed sheets

            Clinical microbiologist issues warning over hidden ‘droppings’ in bed sheets

            Scientists just found a sugar switch that ‘protects your brain from Alzheimer’s’

            Scientists just found a sugar switch that ‘protects your brain from Alzheimer’s’

            Brain dead pregnant woman’s family issue update after baby cut from her body

            Brain dead pregnant woman’s family issue update after baby cut from her body

          • Entertainment
            Tesco shoppers ‘run’ to stores for ‘gorgeous’ £29.50 cardigan

            Tesco shoppers ‘run’ to stores for ‘gorgeous’ £29.50 cardigan

            Former DWP employee urges all parents to claim Child Benefit to boost State Pension payments

            Former DWP employee urges all parents to claim Child Benefit to boost State Pension payments

            DWP boss defends welfare reform changes after PIP plans put on hold

            DWP boss defends welfare reform changes after PIP plans put on hold

            People on highest PIP could see payments rise to nearly £800 each month from next April

            People on highest PIP could see payments rise to nearly £800 each month from next April

            Home Bargains’ ‘soft’ £30 coat looks ‘just like’ £175 Dryrobe version

            Home Bargains’ ‘soft’ £30 coat looks ‘just like’ £175 Dryrobe version

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            Fury as Welsh Government rejects recommended 4.8% pay rise for teachers

            Fury as Welsh Government rejects recommended 4.8% pay rise for teachers

            Vocational skills to be offered at new secondary school in Swansea

            Vocational skills to be offered at new secondary school in Swansea

            Lecturer struck off after falling asleep, playing on his phone and describing students as ‘d*** heads’

            Lecturer struck off after falling asleep, playing on his phone and describing students as ‘d*** heads’

            Teacher who drank alcohol in ‘mini-rave’ lesson and swore at pupils is struck off

            Teacher who drank alcohol in ‘mini-rave’ lesson and swore at pupils is struck off

            Pupil referral unit that takes children kicked out of school gets flawless Estyn report

            Pupil referral unit that takes children kicked out of school gets flawless Estyn report

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          Scientists just found a sugar switch that ‘protects your brain from Alzheimer’s’

          by Annie A. McGinnis
          July 4, 2025
          in Health
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          The lead author of a new study believes “our brain’s hidden sugar code could unlock powerful tools for combating dementia”

          Portrait of an elderly woman sitting alone in a senior care facility
          The discovery could lead to new strategies for preventing or slowing Alzheimer’s(Image: Bob Ingelhart)

          Brits with a sweet-tooth might actively try to curb temptation when they feel they have been raiding the cupboards or sweetie drawer too much. However, did you know sugar could actually hold a major brain benefit?

          Scientists have uncovered a surprising sugar-related mechanism inside brain cells that could transform how we fight Alzheimer’s and other dementias.

          In Scotland, an estimated 90,000 people are living with dementia, and approximately 66 per cent of those have Alzheimer’s disease, according to Alzheimer’s Research UK.

          Now, a new study from scientists at the Buck Institute for Research on Aging has revealed a surprising player in the battle against Alzheimer’s disease and other forms of dementia – brain sugar metabolism.

          Published in Nature Metabolism, the research uncovers how breaking down glycogen – a stored form of glucose – in neurons may protect the brain from toxic protein build-up and degeneration.

          Sad senior old woman. Lonely from loss or sick with headache. Upset patient in retirement home with stress or pain. Alzheimer, depression, senility or dementia. Disorder, migraine or insomnia.
          Brain cells use sugar in a surprising way that helps clear out harmful build-up(Image: Getty)

          Glycogen is typically thought of as a reserve energy source stored in the liver and muscles. While small amounts also exist in the brain, its role in neurons has long been dismissed.

          “This new study challenges that view, and it does so with striking implications,” says Professor Pankaj Kapahi, PhD, senior scientist on the study. “Stored glycogen doesn’t just sit there in the brain; it is involved in pathology.”

          The researchers discovered that in both fly and human models of tauopathy (a group of neurodegenerative diseases including Alzheimer’s), neurons accumulate excessive glycogen.

          More importantly, this build-up appears to contribute to disease progression. But tau, the protein that clumps into tangles in Alzheimer’s patients, appears to physically bind to glycogen, trapping it and preventing its breakdown.

          Woman holding senior woman's hand on bed
          The number of deaths attributed to dementia has increased significantly in recent years, as per Alzheimer’s Research UK(Image: Barcin)

          When glycogen can’t be broken down, the neurons lose an essential mechanism for managing oxidative stress, a key feature in aging and neurodegeneration. By restoring the activity of an enzyme called glycogen phosphorylase (GlyP), researchers found they could reduce tau-related damage in fruit flies and human stem cell-derived neurons.

          “By increasing GlyP activity, the brain cells could better detoxify harmful reactive oxygen species, thereby reducing damage and even extending the lifespan of tauopathy model flies,” said postdoc Sudipta Bar.

          Even more promising, the team demonstrated that restricting one’s diet naturally enhanced GlyP activity and improved tau-related outcomes in flies. They further mimicked these effects and showed that the benefits of DR might be reproduced through drug-based activation of this sugar-clearing system.

          “This work could explain why GLP-1 drugs, now widely used for weight loss, show promise against dementia, potentially by mimicking dietary restriction,” said Kapahi.

          “Work in this simple animal allowed us to move into human neurons in a much more targeted way.”

          Kapahi says this study not only highlights glycogen metabolism as an unexpected hero in the brain but also opens up a new direction in the search for treatments against Alzheimer’s and related diseases.

          “As we continue to age as a society, findings like these offer hope that better understanding – and perhaps rebalancing – our brain’s hidden sugar code could unlock powerful tools for combating dementia,” he added.

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